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ChemicalBook > Product Catalogue >API >Specialty drugs >Antidote >Disulfiram

Disulfiram

Disulfiram Structure
  • ₹2000 - ₹13033.3
  • Product name: Disulfiram
  • CAS: 97-77-8
  • MF: C10H20N2S4
  • MW: 296.54
  • EINECS:202-607-8
  • MDL Number:MFCD00009048
  • Synonyms:Tillram;TTS x;Tuads, ethyl;1,1’-dithiobis(n,n-diethylthio-formamid ;1,1’-dithiobis(n,n-diethylthioformamide) ;1,1'-Dithiobis(N,N-diethylthioformamide);Abstenisil ;Abstensil
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1G
  • 25G
  • 50G
  • 250G
  • 500G
  • 1KG
  • ManufacturerTCI Chemicals (India)
  • Product numberB0479
  • Product descriptionTetraethylthiuram Disulfide
  • Packaging25G
  • Price₹2000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB0479
  • Product descriptionTetraethylthiuram Disulfide
  • Packaging500G
  • Price₹4400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number86720
  • Product descriptionTetraethylthiuram disulfide ≥97.0% (S)
  • Packaging50G
  • Price₹2262.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number86720
  • Product descriptionTetraethylthiuram disulfide ≥97.0% (S)
  • Packaging250G
  • Price₹4373.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1690
  • Product descriptionDisulfiram Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹11961.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number86720
  • Product descriptionTetraethylthiuram disulfide ≥97.0% (S)
  • Packaging1KG
  • Price₹13033.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B0479 Tetraethylthiuram Disulfide 25G ₹2000 2022-05-26 Buy
TCI Chemicals (India) B0479 Tetraethylthiuram Disulfide 500G ₹4400 2022-05-26 Buy
Sigma-Aldrich(India) 86720 Tetraethylthiuram disulfide ≥97.0% (S) 50G ₹2262.43 2022-06-14 Buy
Sigma-Aldrich(India) 86720 Tetraethylthiuram disulfide ≥97.0% (S) 250G ₹4373.3 2022-06-14 Buy
Sigma-Aldrich(India) PHR1690 Disulfiram Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹11961.63 2022-06-14 Buy
Sigma-Aldrich(India) 86720 Tetraethylthiuram disulfide ≥97.0% (S) 1KG ₹13033.3 2022-06-14 Buy

Properties

Melting point :69-71 °C (lit.)
Boiling point :117°C
Density :1.27
vapor pressure :0Pa at 25℃
refractive index :1.5500 (estimate)
Flash point :117°C/17mm
storage temp. :2-8°C
solubility :0.004g/l
pka :0.86±0.50(Predicted)
form :Crystals, Crystalline Powder or Granules
color :Light yellow
Odor :lt. gray powd., sl. odor
Water Solubility :0.02 g/100 mL
Merck :14,3364
BRN :1712560
Exposure limits :ACGIH: TWA 2 mg/m3
NIOSH: TWA 2 mg/m3 Stability :Stable. Incompatible with strong oxidants.
InChIKey :AUZONCFQVSMFAP-UHFFFAOYSA-N
LogP :3.6 at 21℃
CAS DataBase Reference :97-77-8(CAS DataBase Reference)
IARC :3 (Vol. 12, Sup 7) 1987
NIST Chemistry Reference :Disulfiram(97-77-8)
EPA Substance Registry System :Disulfiram (97-77-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P314 Get medical advice/attention if you feel unwell.

Description

Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.

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Suppliers and manufacturers

SNA HEALTHCARE PVT LTD Yasho Industries Ltd Afton Pharma Solara Active Pharma Sciences Ltd East Coast Organics Ralington Pharma Raigad Chemicals Pvt Ltd Rajasthan Antibiotics Ltd Unidrug Innovative Pharma Technologies Ltd REXIN Laboratories (Redson Group)