Dutasteride
- ₹9439.4 - ₹38147.3
- Product name: Dutasteride
- CAS: 164656-23-9
- MF: C27H30F6N2O2
- MW: 528.53
- EINECS:638-758-5
- MDL Number:MFCD00937869
- Synonyms:(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoroMethyl)phenyl]-2,15-diMethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxaMide;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxaMide;(5α,17β)-;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxaMide-13C6;6β-Hydroxy Dutasteride;4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-;Avolve;Dutasteride API
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1221
- Product descriptionDutasteride ≥98% (HPLC)
- Packaging10MG
- Price₹9439.4
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1221
- Product descriptionDutasteride ≥98% (HPLC)
- Packaging50MG
- Price₹38147.3
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1221 | Dutasteride ≥98% (HPLC) | 10MG | ₹9439.4 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1221 | Dutasteride ≥98% (HPLC) | 50MG | ₹38147.3 | 2022-06-14 | Buy |
Properties
Melting point :242-250°C
Boiling point :620.3±55.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear
pka :13.32±0.70(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +18 to +24°, c = 1 in chloroform-d
BCS Class :2/4
InChIKey :JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES :N1[C@@]2([H])[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@]([H])([C@]3([H])CC2)CC[C@@H]4C(NC2=CC(C(F)(F)F)=CC=C2C(F)(F)F)=O)C=CC1=O
Boiling point :620.3±55.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear
pka :13.32±0.70(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +18 to +24°, c = 1 in chloroform-d
BCS Class :2/4
InChIKey :JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES :N1[C@@]2([H])[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@]([H])([C@]3([H])CC2)CC[C@@H]4C(NC2=CC(C(F)(F)F)=CC=C2C(F)(F)F)=O)C=CC1=O
Safety Information
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Signal word: | Danger | ||||||||||||||
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Description
5α-reductase catalyzes the NADPH-dependent reduction of Δ4,5 double bonds in several steroid substrates, including testosterone , which is converted to dihydrotestosterone, the primary mediator of prostate growth. The 5α-reductase enzymes responsible for the reduction of testosterone to dihydrotestosterone exist as two forms: type I, which occurs in the skin, liver, and ventral prostate and type II, which is expressed in ventral prostate, epididymis, and other reproductive tissues. Dutasteride is a time-dependent, dual inhibitor of 5α-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia. Compared to finasteride , a selective inhibitor of type II 5α-reductase, dutasteride has a greater terminal half-life (1 vs. 14 hours in rat, respectively) and is more effective at decreasing serum levels of dihydrotestosterone at single doses > 10 mg. Dutasteride has also been used as a strategy to reduce androgen levels related to prostate tumor burden on androgen receptor activity.More related product prices
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