Edoxaban-d6
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- ₹0
- Product name: Edoxaban-d6
- CAS: 1304701-57-2
- MF: C24H30ClN7O4S
- MW: 548.06
- EINECS:
- MDL Number:MFCD32661438
- Synonyms:Edoxaban-d6;N-[(1S,2R,4S)-4-[bis(trideuteriomethyl)carbamoyl]-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]-N'-(5-chloropyridin-2-yl)oxamide;[2H6]-Edoxaban;Edoxaban hydrochloride salt;2H6]-Edoxaban hydrochloride salt
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :>205°C (dec.)
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :Chloroform (Slightly), Dichloromethane (Slightly)
form :Solid
color :Pale Orange to Pale Red
Stability :Hygroscopic
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :Chloroform (Slightly), Dichloromethane (Slightly)
form :Solid
color :Pale Orange to Pale Red
Stability :Hygroscopic
Safety Information
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Description
Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively). It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.More related product prices
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Suppliers and manufacturers
CLEARSYNTH LABS LTD.
Pharmaffiliates Analytics and Synthetics P. Ltd
SynZeal Research Pvt Ltd
Pharma Affiliates
Cayman Chemical Company
Shanghai Beiwanta Biotechnology Co., Ltd.
Shanghai Yifei Biotechnology Co. , Ltd.
Daicel Chiral Technologies (China)CO.,LTD
Nantong Hanfang Biotechnology Co. , Ltd.
Cato Research Chemicals Inc.