Encorafenib (LGX818)
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- Product name: Encorafenib (LGX818)
- CAS: 1269440-17-6
- MF: C22H27ClFN7O4S
- MW: 540.01
- EINECS:
- MDL Number:MFCD25976758
- Synonyms:LGX 818;LGX-818;(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;Encorafenib (LGX818);Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester;LGX 818 (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;LGX818, >=98%;LGX818, Encorafenib
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Properties
Melting point :184-185°C
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
Safety Information
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.Related product price
- S3I-201
₹11268.83-46038.73 - Tariquidar
₹13791.05-55727.1 - Regorafenib
₹6800-14800
Suppliers and manufacturers
CLEARSYNTH LABS LTD.
SynZeal Research Pvt Ltd
Pharmaffiliates Analytics and Synthetics P. Ltd
Shanghai Rochi Pharmaceutical Co.,Ltd.
Jinan Carbotang Biotech Co.,Ltd.
BOC Sciences
Dideu Industries Group Limited
Baoji Guokang Bio-Technology Co., Ltd.
Zhejiang J&C Biological Technology Co.,Limited
