Epalrestat
|
- ₹7200 - ₹50076.45
- Product name: Epalrestat
- CAS: 82159-09-9
- MF: C15H13NO3S2
- MW: 319.4
- EINECS:675-018-0
- MDL Number:MFCD00865484
- Synonyms:5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet ;e)-(e ;EPALRESTAT;(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid;AKOS BBS-00007767;OTAVA-BB BB7211260020;Epalrest;Epalrestat, 99.5%
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 1G
- 5G
- ManufacturerTCI Chemicals (India)
- Product numberE0906
- Product descriptionEpalrestat
- Packaging1G
- Price₹7200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberE0906
- Product descriptionEpalrestat
- Packaging5G
- Price₹9800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0527
- Product descriptionEpalrestat ≥98% (HPLC)
- Packaging50MG
- Price₹50076.45
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0527
- Product descriptionEpalrestat ≥98% (HPLC)
- Packaging10MG
- Price₹12297.2
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | E0906 | Epalrestat | 1G | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0906 | Epalrestat | 5G | ₹9800 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML0527 | Epalrestat ≥98% (HPLC) | 50MG | ₹50076.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0527 | Epalrestat ≥98% (HPLC) | 10MG | ₹12297.2 | 2022-06-14 | Buy |
Properties
Melting point :210-217 C
Boiling point :516.8±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.62±0.10(Predicted)
form :powder
color :yellow to orange
Merck :14,3605
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI :InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey :CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES :S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Boiling point :516.8±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.62±0.10(Predicted)
form :powder
color :yellow to orange
Merck :14,3605
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI :InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey :CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES :S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Aldose reductase, the first enzyme of the polyol pathway, converts glucose to sorbitol in the presence of NADPH. Increased aldose reductase expression, induced by hyperglycemia, has been associated with complications of diabetes, as it can create a metabolic imbalance in tissues dependent on insulin for the uptake of glucose. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). At 10 nM, it can suppress high glucose-induced proliferation of vascular smooth muscle cells and at 100 nM it can prevent high glucose-induced intracellular NADH/NAD+ increase and membrane-bound protein kinase C activation. Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.Related product price
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