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FILIPIN III

FILIPIN III Structure
  • ₹17915.38 - ₹59818.95
  • Product name: FILIPIN III
  • CAS: 480-49-9
  • MF: C35H58O11
  • MW: 654.83
  • EINECS:
  • MDL Number:MFCD30742956
  • Synonyms:filimarisin ;28-dimethyl--3-(1-hydroxyhexyl)-1 ;1',26-Dihydroxyfilipin I;15-Deoxylagosin;1'-epi-Filipin IV;1'-Hydroxyfilipin II;FILIPIN III;filipin iii from streptomyces*filipinensis
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberF4767
  • Product descriptionFilipin III from Streptomyces filipinensis ≥85% (HPLC)
  • Packaging1MG
  • Price₹17915.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF4767
  • Product descriptionFilipin III from Streptomyces filipinensis ≥85% (HPLC)
  • Packaging5MG
  • Price₹59818.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) F4767 Filipin III from Streptomyces filipinensis ≥85% (HPLC) 1MG ₹17915.38 2022-06-14 Buy
Sigma-Aldrich(India) F4767 Filipin III from Streptomyces filipinensis ≥85% (HPLC) 5MG ₹59818.95 2022-06-14 Buy

Properties

Melting point :163-180° (Bergy, Eble)
alpha :D25 -245° (c = 0.8 in DMF)
Boiling point :913.9±65.0 °C(Predicted)
Density :1.161±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in Methanol (up to 10 mg/ml)
form :solid
pka :12.77±0.70(Predicted)
color :White or light yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cholesterol is both an important structural component of cell membranes and an early intermediate in hormone and bile acid biosynthesis. The localization and measurement of cholesterol in cells is therefore of great interest. Filipin is the collective name given to four isomeric polyene macrolides isolated from cultures of S. filipinensis; Filipin III is the predominant isomer and the one used in most studies. Filipin binds to cholesterol in membranes, forming ultrastructural aggregates and complexes which can be visualized by freeze-fracture electron microscopy. The binding of cholesterol also decreases the intrinsic fluorescence of Filipin, and this property has also been used to detect cholesterol in membrane fractions.

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