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ChemicalBook > Product Catalogue >API >Respiratory Drugs >Asthma drugs >Formoterol fumarate

Formoterol fumarate

Formoterol fumarate Structure
  • ₹0
  • Product name: Formoterol fumarate
  • CAS: 43229-80-7
  • MF: C42H52N4O12
  • MW: 804.88
  • EINECS:1308068-626-2
  • MDL Number:MFCD03093863
  • Synonyms:formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin ;o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt),dihydrate ;(+/-)-(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL] FORMAMIDE HEMIFUMARATE;(R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE;(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE;Formoterol fumarate JP13;Formoterol fumarate 50 gram;FORMATEROL FUMATATE
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :138-140°C
storage temp. :Room temperature
solubility :Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
pka :pKa1 7.9; pKa2 9.2(at 25℃)
form :Solid
color :White to off-white
λmax :284nm(lit.)
Merck :14,4245
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Formoterol is an agonist of β-adrenergic receptors that activates the β1, β2, and β3 receptors with pEC50 values of 7.5, 9.0, and 6.8 respectively. It displays high selectivity for β-adrenoceptors in the trachea over those in atria. Formoterol activity is retained in the airway for extended periods, so it is classified as a long-acting β-receptor agonist. It has use, alone or in combination with other compounds, in chronic obstructive pulmonary disease and asthma.

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