GDC-0152
|
- ₹0
- Product name: GDC-0152
- CAS: 873652-48-3
- MF: C25H34N6O3S
- MW: 498.64
- EINECS:
- MDL Number:MFCD26142660
- Synonyms:GDC-0152;(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;GDC0152;GDC 0152.;CS-2247;GDC-0152; GDC0152; GDC 0152.;GDC-0152 USP/EP/BP;GDC-0152,IAP,Inhibitor,inhibit,GDC 0152
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :175-177oC
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively). GDC-0152 induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells. It is orally bioavailable and suppresses tumor growth in breast cancer xenografts in mice. GDC-0152 also induces NF-κB transcriptional activity, resulting in the expression of several cytokines, including TNF-α. In dogs and rats, but not humans, this leads to a pronounced inflammatory response.More related product prices
Birinapant 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide 779353-01-4 MK-2206 2HCl 936091-14-4 Ceritinib (LDK378)