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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Contraceptives >(-)-Gossypol

(-)-Gossypol

(-)-Gossypol Structure
  • ₹0
  • Product name: (-)-Gossypol
  • CAS: 90141-22-3
  • MF: C30H30O8
  • MW: 518.55
  • EINECS:
  • MDL Number:MFCD00017352
  • Synonyms:AT 101, >=98%;DL-gossypol acetic acid;(R)-(-)-Gossypol;(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde;(R)-Gossypol;R-(-)-gossypol acetic acid;GOSSYPOL 90141-22-3;CS-619
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :166-167℃
alpha :D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3)
Boiling point :707.9±55.0 °C(Predicted)
Density :1.403
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :7.15±0.50(Predicted)
color :white to light brown
optical activity :[α]/D -350 to -365°, c = 0.3 (CDCl3)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

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