GSK 2330672
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- Product name: GSK 2330672
- CAS: 1345982-69-5
- MF: C28H38N2O7S
- MW: 546.68
- EINECS:604-604-1
- MDL Number:MFCD28386358
- Synonyms:GSK 2330672;GSK 2330672; GSK-2330672;3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid;Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-;CS-2639;Iinerixibat;Iinerixibat (GSK2330672);linerixibat
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Properties
Boiling point :730.8±60.0 °C(Predicted)
Density :1.218±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form :A crystalline solid
pka :3.27±0.10(Predicted)
color :White to off-white
Density :1.218±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form :A crystalline solid
pka :3.27±0.10(Predicted)
color :White to off-white
Safety Information
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Description
GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited
Guangzhou Weijia Technology Co., Ltd.