GSK 2801
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- Product name: GSK 2801
- CAS: 1619994-68-1
- MF: C20H21NO4S
- MW: 371.45
- EINECS:
- MDL Number:MFCD26142953
- Synonyms:GSK 2801;GSK2801;GSK-2801;1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone;1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone;1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone;Ethanone, 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]-;GSK-2801; GSK 280
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Properties
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
color :Light yellow to khaki
storage temp. :-20°C
solubility :insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
color :Light yellow to khaki
Safety Information
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Description
BAZ2A/B are bromodomain-containing proteins whose biological function is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci. BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the expression of noncoding RNAs. GSK2801 is a selective, cell-permeable inhibitor of the BAZ2 family of bromodomain-containing proteins (IC50s = 9-350 nM in a BAZ2B AlphaScreen). It binds to BAZ2A and BAZ2B with Kd values of 0.26 and 0.14 μM, respectively, and does not interact with the bromodomains of BRD4(BD1), CREBBP, TRIM24/TIF1α, PB1(BD5), PCAF, or ATAD2. See the Structural Genomics Consortium (SGC) website for more information.Suppliers and manufacturers
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
