GSK-3BETA INHIBITOR XII
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- ₹4000 - ₹52599.99
- Product name: GSK-3BETA INHIBITOR XII
- CAS: 601514-19-6
- MF: C18H14N4O2
- MW: 318.33
- EINECS:
- MDL Number:MFCD09037535
- Synonyms:TWS119;GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119;TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol;GSK-3β Inhibitor, TWS119
6 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberT3605
- Product descriptionTWS 119
- Packaging5MG
- Price₹4000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT3605
- Product descriptionTWS 119
- Packaging25MG
- Price₹9700
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1271
- Product descriptionTWS119 ≥98% (HPLC)
- Packaging5MG
- Price₹11100
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361554
- Product descriptionGSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is
- Packaging1MG
- Price₹16670.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1271
- Product descriptionTWS119 ≥98% (HPLC)
- Packaging25MG
- Price₹44721.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361554
- Product descriptionGSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is
- Packaging5MG
- Price₹52599.99
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | T3605 | TWS 119 | 5MG | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3605 | TWS 119 | 25MG | ₹9700 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML1271 | TWS119 ≥98% (HPLC) | 5MG | ₹11100 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is | 1MG | ₹16670.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1271 | TWS119 ≥98% (HPLC) | 25MG | ₹44721.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is | 5MG | ₹52599.99 | 2022-06-14 | Buy |
Properties
Melting point :249 °C
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
form :powder
pka :8.99±0.10(Predicted)
color :white to beige
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
form :powder
pka :8.99±0.10(Predicted)
color :white to beige
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.Related product price
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