4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione Structure](/CAS/GIF/865854-05-3.gif)
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- ₹12719.38 - ₹51180.6
- Product name: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
- CAS: 865854-05-3
- MF: C19H14N2O2S
- MW: 334.39
- EINECS:640-411-8
- MDL Number:MFCD18633296
- Synonyms:4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;Tideglusib(NP-031112);TIDEGLUSIB;NP-12;NP031112;NP 031112;NP-031112;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Destructible;Tideglusib (NP031112, NP-12)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0339
- Product descriptionTideglusib ≥98% (HPLC)
- Packaging10MG
- Price₹12719.38
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0339
- Product descriptionTideglusib ≥98% (HPLC)
- Packaging50MG
- Price₹51180.6
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0339 | Tideglusib ≥98% (HPLC) | 10MG | ₹12719.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0339 | Tideglusib ≥98% (HPLC) | 50MG | ₹51180.6 | 2022-06-14 | Buy |
Properties
Melting point :148 - 150oC
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :-1.51±0.20(Predicted)
color :white to beige
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :-1.51±0.20(Predicted)
color :white to beige
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N
Safety Information
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Description
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 . Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 μM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.More related product prices
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![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione](/ProductImageEN/2021-06/small/f2f2c46d-4935-4444-8437-e25fbb26706b.jpg){kind=small}
![4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione](https://img.chemicalbook.com/ProductImageEN/2018-8/small/2da68b40-4188-4530-b786-a1dff3bd4510.jpg){kind=small}