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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Quinolones >Gatifloxacin

Gatifloxacin

Gatifloxacin Structure
  • ₹0
  • Product name: Gatifloxacin
  • CAS: 112811-59-3
  • MF: C19H22FN3O4
  • MW: 375.39
  • EINECS:664-293-2
  • MDL Number:MFCD00895399
  • Synonyms:GATIFLOXACIN;1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-(3-METHYLPIPERAZIN-1-YL)-4-OXO-3-QUINOLINECARBOXYLIC ACID;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDROXY-8-METHOXY-7-(3-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID;Gatifloxacin API;1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(3-METHYL-PIPERAZIN-1-YL)-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID;AKOS NCG1-0010;Gatifloxacin(AM-1155)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :162°C
Boiling point :607.8±55.0 °C(Predicted)
Density :1.386±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
pka :6.43±0.50(Predicted)
form :White to yellow crystalline powder.
color :White to Off-White
InChI :InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey :XUBOMFCQGDBHNK-UHFFFAOYSA-N
SMILES :N1(C2CC2)C2=C(C=C(F)C(N3CCNC(C)C3)=C2OC)C(=O)C(C(O)=O)=C1
CAS DataBase Reference :112811-59-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml). It is much less effective against HeLa cell topoisomerase II (IC50 = 265 μg/ml). Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia in older adults. It remains useful for resolving bacterial conjunctivitis.

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Clinafloxacin Moxifloxacin Levofloxacin hydrochloride Ciprofloxacin 112811-59-3 112811-71-9 6480-68-8 Hydrogen

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Suppliers and manufacturers

J S LABS Varanous Labs Pvt Ltd PANCHSHEEL ORGANICS LTD Aspen Biopharma Labs Pvt Ltd HRV Global Life Sciences LUPIN LTD A.J Chemicals CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd Triveni chemicals