Gatifloxacin
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- ₹0
- Product name: Gatifloxacin
- CAS: 112811-59-3
- MF: C19H22FN3O4
- MW: 375.39
- EINECS:664-293-2
- MDL Number:MFCD00895399
- Synonyms:GATIFLOXACIN;1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-(3-METHYLPIPERAZIN-1-YL)-4-OXO-3-QUINOLINECARBOXYLIC ACID;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDROXY-8-METHOXY-7-(3-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID;Gatifloxacin API;1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(3-METHYL-PIPERAZIN-1-YL)-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID;AKOS NCG1-0010;Gatifloxacin(AM-1155)
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Properties
Melting point :162°C
Boiling point :607.8±55.0 °C(Predicted)
Density :1.386±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
pka :6.43±0.50(Predicted)
form :White to yellow crystalline powder.
color :White to Off-White
InChI :InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey :XUBOMFCQGDBHNK-UHFFFAOYSA-N
SMILES :N1(C2CC2)C2=C(C=C(F)C(N3CCNC(C)C3)=C2OC)C(=O)C(C(O)=O)=C1
CAS DataBase Reference :112811-59-3(CAS DataBase Reference)
Boiling point :607.8±55.0 °C(Predicted)
Density :1.386±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
pka :6.43±0.50(Predicted)
form :White to yellow crystalline powder.
color :White to Off-White
InChI :InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey :XUBOMFCQGDBHNK-UHFFFAOYSA-N
SMILES :N1(C2CC2)C2=C(C=C(F)C(N3CCNC(C)C3)=C2OC)C(=O)C(C(O)=O)=C1
CAS DataBase Reference :112811-59-3(CAS DataBase Reference)
Safety Information
Symbol(GHS): |
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Description
Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml). It is much less effective against HeLa cell topoisomerase II (IC50 = 265 μg/ml). Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia in older adults. It remains useful for resolving bacterial conjunctivitis.More related product prices
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