Gefitinib-d6
- ₹0
- Product name: Gefitinib-d6
- CAS: 1228664-49-0
- MF: C22H24ClFN4O3
- MW: 446.91
- EINECS:
- MDL Number:MFCD21363632
- Synonyms:Gefitinib-d6;Hexadeuterated gefitinib;[2H6]-Gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
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Properties
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form :A solid
color :White to off-white
solubility :DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form :A solid
color :White to off-white
Safety Information
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Description
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).More related product prices
3-Chloro-4-fluoroaniline 3-Hydroxy-4-methoxybenzonitrile Gefitinib 7357-67-7 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 13794-72-4 3,4-Dichloroaniline 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetateRelated product price
- 3-Chloro-4-fluoroaniline
₹414-23120.01 - Gefitinib
₹4200-45778.93 - 7357-67-7
₹2900-11844
Suppliers and manufacturers
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Shanghai Hao Zhun Biological Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
United States Biological
Nanjing XiZe Biotechnology CO., Ltd.
Shanghai isotope chemical co.,ltd
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Cayman Chemical Company
Shanghai Beiwanta Biotechnology Co., Ltd.
Shanghai YuZn Pharm. Technology Co.,Ltd.