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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Gemfibrozil

Gemfibrozil

Gemfibrozil Structure
  • ₹5260.95 - ₹32052.83
  • Product name: Gemfibrozil
  • CAS: 25812-30-0
  • MF: C15H22O3
  • MW: 250.33
  • EINECS:247-280-2
  • MDL Number:MFCD00079335
  • Synonyms:PENTANOIC ACID, 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYL-;5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID;5-(2,5-DIMETHYL-PHENOXY)-2,2-DIMETHYL-PENTANOIC ACID;2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID;2,2-DIMETHYL-5-(2,5-XYLYLOXY) VALERIC ACID;GEMFIBROZIL;Gemcitabine intermediates;5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1G
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberG0368
  • Product descriptionGemfibrozil min. 98.0 %
  • Packaging5G
  • Price₹6800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberG0368
  • Product descriptionGemfibrozil min. 98.0 %
  • Packaging25G
  • Price₹9700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number91823
  • Product descriptionGemfibrozil analytical standard
  • Packaging100MG
  • Price₹5260.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1286
  • Product descriptionGemfibrozil Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8107.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG9518
  • Product descriptionGemfibrozil
  • Packaging5G
  • Price₹9666.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG9518
  • Product descriptionGemfibrozil
  • Packaging25G
  • Price₹32052.83
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) G0368 Gemfibrozil min. 98.0 % 5G ₹6800 2022-05-26 Buy
TCI Chemicals (India) G0368 Gemfibrozil min. 98.0 % 25G ₹9700 2022-05-26 Buy
Sigma-Aldrich(India) 91823 Gemfibrozil analytical standard 100MG ₹5260.95 2022-06-14 Buy
Sigma-Aldrich(India) PHR1286 Gemfibrozil Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8107.93 2022-06-14 Buy
Sigma-Aldrich(India) G9518 Gemfibrozil 5G ₹9666.73 2022-06-14 Buy
Sigma-Aldrich(India) G9518 Gemfibrozil 25G ₹32052.83 2022-06-14 Buy

Properties

Melting point :61-63°C
Boiling point :158-159 C
Density :1.1109 (rough estimate)
refractive index :1.5020 (estimate)
storage temp. :2-8°C
solubility :Practically insoluble in water, very soluble in methylene chloride, freely soluble in anhydrous ethanol and in methanol.
form :powder
pka :4.75±0.45(Predicted)
color :White to Off-White
Water Solubility :>0.5g/L(temperature not stated)
Merck :14,4388
BCS Class :2
CAS DataBase Reference :25812-30-0(CAS DataBase Reference)
IARC :3 (Vol. 66) 1996
EPA Substance Registry System :Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- (25812-30-0)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy. It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy. Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia. Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM). Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.

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Suppliers and manufacturers

Cadila Pharmaceuticals Ltd ANWITA APIS Apotex Pharmachem India Pvt Ltd Hikal Ltd. Ralington Pharma Sachem Vapoor Chemicals PIRAMAL PHARMA LTD OCEAN TRADING CORPORATION CADILA PHARMACEUTICALS LTD