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HIRUDIN

HIRUDIN Structure
  • ₹47727.43 - ₹163035.33
  • Product name: HIRUDIN
  • CAS: 8001-27-2
  • MF: C287H440N80O113S7
  • MW: 7043.4877
  • EINECS:232-279-1
  • MDL Number:MFCD00081692
  • Synonyms:hirudex ;recombinanthirudin ;HIRUDIN RECOMBINANT;DESULFATO-HIRUDIN;DESULFO-HIRUDIN;NATIVE HIRUDIN;[TYR63]HIRUDIN (HV1), LEECH;(63-tyrosine)hirudin (hv1),leech,rec. F. yeast
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1EA
  • 100UNITS
  • 500UNITS
  • ManufacturerSigma-Aldrich(India)
  • Product numberH0393
  • Product descriptionHirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
  • Packaging100UNITS
  • Price₹47727.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number94581
  • Product descriptionHirudin recombinant from yeast lyophilized powder, white, >1500?U/vial
  • Packaging1EA
  • Price₹114420.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH0393
  • Product descriptionHirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
  • Packaging500UNITS
  • Price₹163035.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) H0393 Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) 100UNITS ₹47727.43 2022-06-14 Buy
Sigma-Aldrich(India) 94581 Hirudin recombinant from yeast lyophilized powder, white, >1500?U/vial 1EA ₹114420.25 2022-06-14 Buy
Sigma-Aldrich(India) H0393 Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) 500UNITS ₹163035.33 2022-06-14 Buy

Properties

storage temp. :2-8°C
form :lyophilized powder
color :white
Merck :13,4737

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.

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