HOE-140
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- ₹28653.78
- Product name: HOE-140
- CAS: 138614-30-9
- MF: C59H89N19O13S.C2H4O2
- MW: 1364.59
- EINECS:206-141-6
- MDL Number:MFCD04112967
- Synonyms:Firazyr;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg;Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg;HOE 140 Acetate;lcatibant Acetate;HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 250μG
- ManufacturerSigma-Aldrich(India)
- Product numberH157
- Product descriptionHOE 140 ≥94%
- Packaging250μG
- Price₹28653.78
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H157 | HOE 140 ≥94% | 250μG | ₹28653.78 | 2022-06-14 | Buy |
Properties
storage temp. :-20°C
solubility :DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM) form :A crystalline solid
color :White to off-white
solubility :DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM) form :A crystalline solid
color :White to off-white
Safety Information
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Description
Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.Related product price
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Suppliers and manufacturers
Biophore India Pharmaceuticals Pvt Ltd
Mylan Laboratories Ltd
CLEARSYNTH LABS LTD.
Pharmaffiliates Analytics and Synthetics P. Ltd
Pharma Affiliates
SynZeal Research Pvt Ltd