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ChemicalBook > Product Catalogue >Organic Chemistry >Carboxylic acids and derivatives >Carboxylic acid esters and derivatives >Halobetasol propionate

Halobetasol propionate

Halobetasol propionate Structure
  • ₹5500 - ₹8200
  • Product name: Halobetasol propionate
  • CAS: 66852-54-8
  • MF: C25H31ClF2O5
  • MW: 484.96
  • EINECS:686-247-0
  • MDL Number:MFCD00866013
  • Synonyms:ulobetasol propionate;HALOBETASOL PROPIONATE;BMY-30056;CGP-14458;Uiobetasol Propionate;Ultravate;21-chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate;6 alpha-fluoroclobetasol 17-propionate
2 prices
Selected condition:

Brand

  • TCI Chemicals (India)

Package

  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberH1457
  • Product descriptionHalobetasol Propionate
  • Packaging25MG
  • Price₹5500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberH1457
  • Product descriptionHalobetasol Propionate
  • Packaging100MG
  • Price₹8200
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) H1457 Halobetasol Propionate 25MG ₹5500 2022-05-26 Buy
TCI Chemicals (India) H1457 Halobetasol Propionate 100MG ₹8200 2022-05-26 Buy

Properties

Melting point :213-215°C
Boiling point :570.7±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.55±0.70(Predicted)
color :White to Off-White
InChIKey :BDSYKGHYMJNPAB-QNGYMBKVNA-N
SMILES :O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,9,17,19,21,24,r|
CAS DataBase Reference :66852-54-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.  It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.

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