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Hh-Ag 1.3

Hh-Ag 1.3 Structure
  • ₹21460
  • Product name: Hh-Ag 1.3
  • CAS: 364590-63-6
  • MF: C28H28ClN3OS
  • MW: 490.06
  • EINECS:-0
  • MDL Number:MFCD14636155
  • Synonyms:3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Smoothened Agonist, HCl;SAG . dihydrochloride (water soluble);Hh-Ag 1.3;3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride;Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-;Frizzled6 agonist SAG1.3
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product number566660
  • Product descriptionSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo hept
  • Packaging1MG
  • Price₹21460
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 566660 Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo hept 1MG ₹21460 2022-06-14 Buy

Properties

Boiling point :688.6±55.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
pka :10?+-.0.40(Predicted)
form :White to off-white solid.
Water Solubility :Soluble in water.
Sensitive :Light Sensitive & Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.

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