IC 261

₹7300 - ₹17860
Product name: IC 261
CAS: 186611-52-9
MF: C18H17NO4
MW: 311.335
EINECS:
MDL Number:MFCD00118156
Synonyms:SU5607, 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one;1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607;SU-5607 IC 261;(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one;IC261, >98%;IC-261(SU-5607);IC261 - CAS 186611-52-9 - Calbiochem;IC261;SU5607;IC 261;SU 5607

Price4 Properties Safety Information Description

4 prices

Selected condition：

Brand

TCI Chemicals (India)
Sigma-Aldrich(India)

Package

5MG
10MG
50MG

ManufacturerTCI Chemicals (India)
Product numberI1077
Product descriptionIC 261
Packaging10MG
Price₹7300
Updated2022-05-26
Buy

ManufacturerTCI Chemicals (India)
Product numberI1077
Product descriptionIC 261
Packaging50MG
Price₹14200
Updated2022-05-26
Buy

ManufacturerSigma-Aldrich(India)
Product numberI0658
Product descriptionIC 261 ≥98% (HPLC)
Packaging5MG
Price₹15544.7
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product number400090
Product descriptionIC261 - CAS 186611-52-9 - Calbiochem A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC?? = 0.7-1.3 μM) and CK1ε (IC?? = 0.6-1.4 μM
Packaging5MG
Price₹17860
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
TCI Chemicals (India)	I1077	IC 261	10MG	₹7300	2022-05-26	Buy
TCI Chemicals (India)	I1077	IC 261	50MG	₹14200	2022-05-26	Buy
Sigma-Aldrich(India)	I0658	IC 261 ≥98% (HPLC)	5MG	₹15544.7	2022-06-14	Buy
Sigma-Aldrich(India)	400090	IC261 - CAS 186611-52-9 - Calbiochem A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC?? = 0.7-1.3 μM) and CK1ε (IC?? = 0.6-1.4 μM	5MG	₹17860	2022-06-14	Buy

Properties

Melting point :214 °C
storage temp. :protect from light
solubility :DMSO: 18 mg/mL soluble
form :solid
color :yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1δ and CK1? (IC50 = ~1 μM for both), as well as CK1α (IC50 = 16 μM). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC 261, at 1 μM, inhibits cytokinesis in primary mouse embryo fibroblasts. IC261 is used to elucidate the role of CK1 in cells and in whole organisms.

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