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ChemicalBook > Product Catalogue >API >Fluid, Electrolyte, and Acid-Base Balance >Electrolyte Balance Pharmacology >Ibandronic acid

Ibandronic acid

Ibandronic acid Structure
  • ₹0
  • Product name: Ibandronic acid
  • CAS: 114084-78-5
  • MF: C9H23NO7P2
  • MW: 319.23
  • EINECS:
  • MDL Number:MFCD00868772
  • Synonyms:{1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid;[1-Hydroxy-3-(methyl-d3-pentylamino)propylidene]bisphosphnic Acid;IBANDRONIC ACID-D3;1-Hydroxy-3-(methylpentylamino)propylidene bisphosphonic acid;Ibandronic acid;P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid;Ibadronic Acid;Ibandronate Acid
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :113-115°C
Boiling point :587.8±60.0 °C(Predicted)
Density :1.449±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka :1.60±0.10(Predicted)
form :Solid
color :White to Off-White
Stability :Hygroscopic
CAS DataBase Reference :114084-78-5(CAS DataBase Reference)
EPA Substance Registry System :Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.

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