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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >Adrenergic Receptor Inhibitors >Ivabradine hydrochloride

Ivabradine hydrochloride

Ivabradine hydrochloride Structure
  • ₹9645.08 - ₹37530.28
  • Product name: Ivabradine hydrochloride
  • CAS: 148849-67-6
  • MF: C27H37ClN2O5
  • MW: 505.05
  • EINECS:638-798-3
  • MDL Number:MFCD00929899
  • Synonyms:Ivabradine hydrochloride;3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;Ivabradine hydrochloride, >=99%;IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride;Corlentor;S-16257;(7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride
Price4 Properties Safety Information Description
4 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberI0847
  • Product descriptionIvabradine Hydrochloride
  • Packaging200MG
  • Price₹9700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberI0847
  • Product descriptionIvabradine Hydrochloride
  • Packaging1G
  • Price₹25500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0281
  • Product descriptionIvabradine hydrochloride ≥98% (HPLC)
  • Packaging10MG
  • Price₹9645.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0281
  • Product descriptionIvabradine hydrochloride ≥98% (HPLC)
  • Packaging50MG
  • Price₹37530.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) I0847 Ivabradine Hydrochloride 200MG ₹9700 2022-05-26 Buy
TCI Chemicals (India) I0847 Ivabradine Hydrochloride 1G ₹25500 2022-05-26 Buy
Sigma-Aldrich(India) SML0281 Ivabradine hydrochloride ≥98% (HPLC) 10MG ₹9645.08 2022-06-14 Buy
Sigma-Aldrich(India) SML0281 Ivabradine hydrochloride ≥98% (HPLC) 50MG ₹37530.28 2022-06-14 Buy

Properties

Melting point :193-196?C
alpha :58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp. :2-8°C
solubility :H2O: ≥5mg/mL (warmed)
form :powder
color :white to beige
optical activity :[α]/D +5 to +9°, c = 1 in DMSO
Merck :14,5247
InChIKey :HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES :C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
CAS DataBase Reference :148849-67-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

Ivabradine is a highly selective open channel blocker that targets the mixed Na+/K+ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN) channels. It suppresses channel activity at HCN1, HCN2, and HCN4, all with the same EC50 value of 4 μM. Notably, ivabradine selectively targets cardiac signaling, resulting in resting heart rate reducing (bradycardic) effects.

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