KAHWEOL
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- ₹0
- Product name: KAHWEOL
- CAS: 6894-43-5
- MF: C20H26O3
- MW: 314.42
- EINECS:
- MDL Number:MFCD00171665
- Synonyms:5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-,(3bS,5aS,7R,8R,10aR,10bS)-;KAHWEOL;(3bS)-3b,4,5,6,7,8,9,10,10aα,10b-Decahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;[3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta)]-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;KAHWEOL USP/EP/BP;Kahweol DISCONTINUED, unstable
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Properties
Melting point :88-90℃
Boiling point :476.6±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMF:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:18.17(Max Conc. mg/mL);57.77(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.02(Max Conc. mg/mL);0.06(Max Conc. mM) pka :14.43±0.40(Predicted)
form :White to off-white solid.
color :Off-white to light yellow
LogP :3.380 (est)
Boiling point :476.6±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMF:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:18.17(Max Conc. mg/mL);57.77(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.02(Max Conc. mg/mL);0.06(Max Conc. mM) pka :14.43±0.40(Predicted)
form :White to off-white solid.
color :Off-white to light yellow
LogP :3.380 (est)
Safety Information
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Description
Kahweol is a natural diterpene that is isolated from coffee beans. It increases glutathione S-transferase activity in the gut mucosa of mice and, with the diterpene cafestol, induces glutathione S-transferase expression in rat livers. Kahweol has anti-inflammatory effects in RAW macrophages, inhibiting LPS-induced nitric oxide and prostaglandin E2 production (IC50 = 54 and 23 μM, respectively). Kahweol also is antiangiogenic, blocking the proliferation of endothelial cells (IC50 = 50 μM) and inhibiting endothelial migration, invasion, and tube formation. Kahweol is easily oxidized in the presence of air.Related product price
- CAFESTOL
₹32341-54237