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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antifungal Drugs >Ketoconazole

Ketoconazole

Ketoconazole Structure
  • ₹6400 - ₹46612.45
  • Product name: Ketoconazole
  • CAS: 65277-42-1
  • MF: C26H28Cl2N4O4
  • MW: 531.43
  • EINECS:265-667-4
  • MDL Number:MFCD00058579
  • Synonyms:,3-dioxolan-4-yl)methoxy)phenyl)-,cis- ;fungarest ;fungoral ;ketoderm ;ketoisdin ;kw-1414 ;orifungalm ;panfungol
8 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 50MG
  • 100MG
  • 1G
  • 1ML
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberK0045
  • Product descriptionKetoconazole
  • Packaging1G
  • Price₹6400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberK0045
  • Product descriptionKetoconazole
  • Packaging5G
  • Price₹20400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1385
  • Product descriptionKetoconazole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹7664.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number420600
  • Product descriptionKetoconazole - CAS 65277-42-1 - Calbiochem An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriati
  • Packaging50MG
  • Price₹11880.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK1003
  • Product descriptionKetoconazole 99.0-101.0% (EP, titration)
  • Packaging100MG
  • Price₹18326.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK-004
  • Product descriptionKetoconazole solution 2.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹18952.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberUC280
  • Product descriptionKetoconazole
  • Packaging5MG
  • Price₹25915.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberUC280
  • Product descriptionKetoconazole
  • Packaging10MG
  • Price₹46612.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) K0045 Ketoconazole 1G ₹6400 2022-05-26 Buy
TCI Chemicals (India) K0045 Ketoconazole 5G ₹20400 2022-05-26 Buy
Sigma-Aldrich(India) PHR1385 Ketoconazole Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹7664.1 2022-06-14 Buy
Sigma-Aldrich(India) 420600 Ketoconazole - CAS 65277-42-1 - Calbiochem An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriati 50MG ₹11880.01 2022-06-14 Buy
Sigma-Aldrich(India) K1003 Ketoconazole 99.0-101.0% (EP, titration) 100MG ₹18326.73 2022-06-14 Buy
Sigma-Aldrich(India) K-004 Ketoconazole solution 2.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹18952.5 2022-06-14 Buy
Sigma-Aldrich(India) UC280 Ketoconazole 5MG ₹25915.05 2022-06-14 Buy
Sigma-Aldrich(India) UC280 Ketoconazole 10MG ₹46612.45 2022-06-14 Buy

Properties

Melting point :148-152 °C
Boiling point :753.4±60.0 °C(Predicted)
Density :1.4046 (rough estimate)
refractive index :-10.5 ° (C=0.4, CHCl3)
Flash point :9℃
storage temp. :2-8°C
solubility :methanol: soluble50mg/mL
pka :pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form :Off-white solid
color :white to light yellow
optical activity :[α]20/D -1 to 1°, c = 4 in methanol
Water Solubility :Soluble in DMSO, ethanol, chloroform, water, and methanol.
Merck :14,5302
BCS Class :2
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XMAYWYJOQHXEEK-OZXSUGGESA-N
LogP :4.350
CAS DataBase Reference :65277-42-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Ketoconazole is an orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase. It potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.

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