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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiepileptic and anticonvulsant >Lacosamide

Lacosamide

Lacosamide Structure
  • ₹0
  • Product name: Lacosamide
  • CAS: 175481-36-4
  • MF: C13H18N2O3
  • MW: 250.29
  • EINECS:605-756-0
  • MDL Number:MFCD08272557
  • Synonyms:LACOSAMIDE;(2R)-2-acetamido-N-benzyl-3-methoxy-propanamide;(2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide;ADD 243037;Erlosamide;Harkoseride;SPM 927;(R)-2-Acetamido-N-benzyl-3-methoxypropanamide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :141-143?C
alpha :D23 +16.0° (c = 1 in CH3OH)
Boiling point :536.4±50.0 °C(Predicted)
Density :1.120±0.06 g/cm3(Predicted)
Flash point :2℃
storage temp. :Refrigerator
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2 mg/ml
form :A crystalline solid
pka :14.19±0.46(Predicted)
InChI :InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChIKey :VPPJLAIAVCUEMN-GFCCVEGCSA-N
SMILES :C(NCC1=CC=CC=C1)(=O)[C@H](NC(C)=O)COC
CAS DataBase Reference :175481-36-4

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Lacosamide (LCM), (SPM 927, (R)-2-acetamido-N-benzyl-3-methoxypropionamide, previously referred to as harkoseride or ADD 234037) is a member of a series of functionalized amino acids that were specifically synthesized as anticonvulsant or antiepileptic drug. It reduces the spread of seizure activity in the brain. Lacosamide appears to have a dual mode of action: selective enhancement of sodium channel inactivation and modulation of collapsin response mediator protein-2.  Compared to novel antiepileptic drugs, lacosamide has broader and higher efficacy, better tolerability, and improved pharmacokinetic properties. Lacosamide is in phase III clinical development for adjunctive treatment of patients with uncontrolled partial-onset seizures, and for monotherapy of patients with painful diabetic neuropathy. It is absorbed rapidly and completely after oral administration. Lacosamide has an elimination half-life of approximately 13 hours and a low potential for drug interactions. Additionally, lacosamide exhibits linear, dose-proportional pharmacokinetics with low intra- and interpatient variability.

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Febuxostat 2-(Acetylamino)-N-(phenylmethyl)-2-propenamide Benzylamine hydrochloride (R)-2-amino-N-benzyl-3-methoxypropanamide Desmethyl Lacosamide Propionamide

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Suppliers and manufacturers

KARPSCHEM LABORATORIES Metrochem API Private Limited Aalidhra Pharmachem Pvt Ltd Lupin Ltd Apotex Pharmachem India Pvt Ltd Alembic Pharmaceuticals Limited Glenmark Pharmaceuticals Limited Hikal Ltd. Hetero Drugs Limited Bajaj Healthcare Ltd