LACTACYSTIN
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- ₹56603.93
- Product name: LACTACYSTIN
- CAS: 133343-34-7
- MF: C15H24N2O7S
- MW: 376.43
- EINECS:200-258-5
- MDL Number:MFCD01076525
- Synonyms:(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER;3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE;(+)-LACTACYSTIN;LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN, STREPTOMYCES SP;LACTACYSTIN, SYNTHETIC;N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 0.2MG
- ManufacturerSigma-Aldrich(India)
- Product numberL6785
- Product descriptionLactacystin ≥90% (HPLC)
- Packaging0.2MG
- Price₹56603.93
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L6785 | Lactacystin ≥90% (HPLC) | 0.2MG | ₹56603.93 | 2022-06-14 | Buy |
Properties
Melting point :233-235°C dec.
Boiling point :714.9±60.0 °C(Predicted)
Density :1.367±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
form :powder
pka :3.11±0.10(Predicted)
color :White to off-white
Water Solubility :Soluble to 10 mM in water
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.
Boiling point :714.9±60.0 °C(Predicted)
Density :1.367±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
form :powder
pka :3.11±0.10(Predicted)
color :White to off-white
Water Solubility :Soluble to 10 mM in water
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.
Safety Information
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Description
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.Related product price
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Suppliers and manufacturers
CLEARSYNTH LABS LTD.
VIVAN Life Sciences Pvt. Limited.
CRO Splendid Lab Private Limited
Xi'an Kono chem co., Ltd.,
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Wuhan Topule Biopharmaceutical Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
Zhengzhou convergence chemical co., LTD
