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LE 300

LE 300 Structure
  • ₹0
  • Product name: LE 300
  • CAS: 274694-98-3
  • MF: C20H22N2
  • MW: 290.4
  • EINECS:
  • MDL Number:MFCD00951284
  • Synonyms:7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE;6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE;6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine;LE 300;5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>91°C (dec.)
storage temp. :Store at RT
solubility :DMSO: 26 mg/mL
form :solid
color :Off-White to Pale Beige
Stability :Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific TargetMol Chemicals Inc. Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. BOC Sciences Nantong QuanYi Biotechnology Co., Ltd Nanjing Tengyi Biotechnology Co., Ltd Labinova AB