LY2940680
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- ₹0
- Product name: LY2940680
- CAS: 1258861-20-9
- MF: C26H24F4N6O
- MW: 512.5
- EINECS:
- MDL Number:MFCD21609264
- Synonyms:Taladegib (LY2940680);4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide LY 2940680;LY2940680;LY2940680 (Taladegib);Taladegib;Taladegib hydrochloride;4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluo;4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide
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Properties
Boiling point :703.5±60.0 °C(Predicted)
Density :1.39
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥5.2 mg/mL in EtOH with ultrasonic; ≥51.3 mg/mL in DMSO with gentle warming and ultrasonic
form :crystalline solid
pka :7.94±0.30(Predicted)
color :White to off-white
Density :1.39
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥5.2 mg/mL in EtOH with ultrasonic; ≥51.3 mg/mL in DMSO with gentle warming and ultrasonic
form :crystalline solid
pka :7.94±0.30(Predicted)
color :White to off-white
Safety Information
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Description
Smoothened (Smo) is a GPCR-like receptor that, with Patched, mediates hedgehog (Hh) signaling to regulate gene expression through the Gli transcription factors. LY2940680 is an antitumor agent that binds to the human Smo receptor and inhibits Sonic Hh-induced Gli1 expression (IC50 = ~2.4 nM in vitro). The potential anticancer activity of LY2940680 is currently under clinical investigation.More related product prices
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