Losmapimod (GW856553X)
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- Product name: Losmapimod (GW856553X)
- CAS: 585543-15-3
- MF: C22H26FN3O2
- MW: 383.46
- EINECS:
- MDL Number:MFCD16619322
- Synonyms:6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide;GW-856553;GSK-AHAB;GW 856553X;LosMapiMod;LosMapiMod,GW-856553;Losmapimod (GW856553X);3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
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Properties
Boiling point :529.4±50.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form :solid
pka :7.75±0.46(Predicted)
color :White to off-white
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form :solid
pka :7.75±0.46(Predicted)
color :White to off-white
Safety Information
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Description
GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.More related product prices
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