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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Analytical Standards >MICROCYSTIN-LR

MICROCYSTIN-LR

MICROCYSTIN-LR Structure
  • ₹0
  • Product name: MICROCYSTIN-LR
  • CAS: 101043-37-2
  • MF: C49H74N10O12
  • MW: 995.17
  • EINECS:621-323-9
  • MDL Number:MFCD00871766
  • Synonyms:5-l-arginine-cyanoginosinl ;5-l-argininecyanoginosinla ;MCYST-LR;5-L-ARGININE-MICROCYSTIN LA;CYANOGINOSIN-LR;Cyanoginosin, Fast-death factor;Cyclo[D-Ala-L-Leu-[(3S)-3-methyl-D-βAsp-]-L-Arg-[(2S,3S)-2-methyl-3-[(1E,3E,5S,6S)-3,5-dimethyl-6-methoxy-7-phenyl-1,3-heptadiene-1-yl]-βAla-]-D-γGlu-N-methyl-Dha-];5-L-Arginine-cyanoginosin
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.29±0.1 g/cm3(Predicted)
Flash point :11 °C
storage temp. :−20°C
solubility :ethanol: 1 mg/mL
pka :3.03±0.70(Predicted)
form :solid film
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
IARC :2B (Vol. 94) 2010
EPA Substance Registry System :Microcystin LR (101043-37-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

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