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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Glycine derivative >NAGLY

NAGLY

NAGLY Structure
  • ₹0
  • Product name: NAGLY
  • CAS: 179113-91-8
  • MF: C22H35NO3
  • MW: 361.52
  • EINECS:
  • MDL Number:MFCD03791313
  • Synonyms:N-ARACHIDONOYL GLYCINE;N-ARACHIDONYL GLYCINE;NAGLY;N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)GLYCINE;ARACHIDONOYL GLYCINE;N-Arachidonoyl glycine (solution in ethanol);Glycine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-;Arachidonyl Glycine
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :560.9±50.0 °C(Predicted)
Density :0.985±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: >5 mg/mL, soluble
form :waxy solid
pka :3.58±0.10(Predicted)
color :off-white
Sensitive :Air Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments. Since it seems to be a very poor ligand for the CB1 receptor, these effects are probably mediated via other signaling pathways.

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