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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >CaMK inhibitors >NH125

NH125

NH125 Structure
  • ₹38634.43 - ₹163067.8
  • Product name: NH125
  • CAS: 278603-08-0
  • MF: C27H45N2.I
  • MW: 524.567
  • EINECS:
  • MDL Number:MFCD07370143
  • Synonyms:1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 ;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;EEF-2 KINASE INHIBITOR;NH125 USP/EP/BP;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberN2162
  • Product descriptionNH125 ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹38634.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN2162
  • Product descriptionNH125 ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹163067.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) N2162 NH125 ≥98% (HPLC), solid 5MG ₹38634.43 2022-06-14 Buy
Sigma-Aldrich(India) N2162 NH125 ≥98% (HPLC), solid 25MG ₹163067.8 2022-06-14 Buy

Properties

Melting point :88.2-94.9 °C
storage temp. :-20°C
solubility :DMSO: 20 mg/mL
form :solid
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NH125 is a cell-permeable imidazolium compound that has been used to study anticancer therapies. eEF2K is an ubiquitous protein kinase that phosphorylates and inactivates eEF2, and thus can modulate the rate of polypeptide chain elongation during translation. NH125 has been shown to inhibit cancer cell growth through inhibition of eukaryotic elongation eEF2K (factor-2 kinase). NH125 induces eEF2 phosphorylation; inhibition of cancer cell growth is correlated with induction of p-eEF2. NH125 is an inhibitor of CaMK.

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