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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Transmembrane Transporters >ATPase inhibitors >(-)-Blebbistatin

(-)-Blebbistatin

(-)-Blebbistatin Structure
  • ₹12080.7 - ₹36718.4
  • Product name: (-)-Blebbistatin
  • CAS: 856925-71-8
  • MF: C18H16N2O2
  • MW: 292.33
  • EINECS:
  • MDL Number:MFCD08460907
  • Synonyms:(-)-BLEBBISTATIN;4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-;(+/-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN;3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (-)-Blebbistatin;3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one 1,2,3,3atetrahydro3ahydroxy6methyl1phenyl4Hpyrrolo[2,3b]quinolin4one;(S)-3a-Hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one;(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem
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Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich
  • Product number203391
  • Product description(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
  • Packaging1MG
  • Price₹21460
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB0560
  • Product description(−)-Blebbistatin solid, synthetic
  • Packaging1MG
  • Price₹12080.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number203391
  • Product description(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
  • Packaging1MG
  • Price₹21460
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB0560
  • Product description(−)-Blebbistatin solid, synthetic
  • Packaging5MG
  • Price₹36718.4
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 203391 (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes. 1MG ₹21460 2022-06-14 Buy
Sigma-Aldrich(India) B0560 (−)-Blebbistatin solid, synthetic 1MG ₹12080.7 2022-06-14 Buy
Sigma-Aldrich(India) 203391 (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes. 1MG ₹21460 2022-06-14 Buy
Sigma-Aldrich(India) B0560 (−)-Blebbistatin solid, synthetic 5MG ₹36718.4 2022-06-14 Buy

Properties

Melting point :210-212°C
Boiling point :507.3±60.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL
form :Yellow solid
pka :11.15±0.20(Predicted)
color :Light Yellow to Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(?)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light, which may be particularly important in fluorescent cell imaging applications.

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