Crenolanib
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- Product name: Crenolanib
- CAS: 670220-88-9
- MF: C26H29N5O2
- MW: 443.54
- EINECS:
- MDL Number:MFCD21609260
- Synonyms:Crenolanib, >=98%;Crenolanib;[1-[2-[5-(3-Methyloxetan-3-ylMethoxy)benziMidazol-1-yl]quinolin-8-yl]piperidin-4-yl]aMine;1-[2-[5-[(3-Methyl-3-oxetanyl)Methoxy]-1H-benziMidazol-1-yl]-8-quinolinyl]-4-piperidinaMine;ARO 002;CP 868596;Crenolanib (CP-868569);Crenolanib (CP-868596)
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Properties
Boiling point :676.6±65.0 °C(Predicted)
Density :1.36
storage temp. :-20°
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).
form :solid
pka :9.84±0.20(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :670220-88-9
Density :1.36
storage temp. :-20°
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).
form :solid
pka :9.84±0.20(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :670220-88-9
Safety Information
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Description
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor α (PDGFRα) and PDGFRβ and Fms-related tyrosine kinase 3 (FLT3; IC50s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations. Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo.More related product prices
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