Ilomastat
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- ₹10670 - ₹59569.98
- Product name: Ilomastat
- CAS: 142880-36-2
- MF: C20H28N4O4
- MW: 388.46
- EINECS:
- MDL Number:MFCD00917040
- Synonyms:(2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide Ilomastat (GM6001, Galardin);Galardin CS 610;Ilomastat, >=98%;(r)-n4-hydroxy-n1-[(s)-2-(1h-indol-3-yl)-1-methylcarbamoly-ethyl]-2-isobutyl-succinamide;galardin tm;(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide;Galardin, GM6001, Ilomastat;SANTACRUZ
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number364205
- Product descriptionGM 6001 - CAS 142880-36-2 - Calbiochem GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases.
- Packaging1MG
- Price₹10670
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number364205
- Product descriptionGM 6001 - CAS 142880-36-2 - Calbiochem GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases.
- Packaging5MG
- Price₹37040
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberM5939
- Product description(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide >95% (HPLC)
- Packaging5MG
- Price₹59569.98
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 364205 | GM 6001 - CAS 142880-36-2 - Calbiochem GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases. | 1MG | ₹10670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 364205 | GM 6001 - CAS 142880-36-2 - Calbiochem GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases. | 5MG | ₹37040 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5939 | (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide >95% (HPLC) | 5MG | ₹59569.98 | 2022-06-14 | Buy |
Properties
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO, and 100% ethanol.
pka :9.16±0.20(Predicted)
form :Off-white solid
color :White
Sensitive :Moisture Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :NITYDPDXAAFEIT-DYVFJYSZSA-N
storage temp. :2-8°C
solubility :Soluble in DMSO, and 100% ethanol.
pka :9.16±0.20(Predicted)
form :Off-white solid
color :White
Sensitive :Moisture Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :NITYDPDXAAFEIT-DYVFJYSZSA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM).More related product prices
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