Elvitegravir
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- Product name: Elvitegravir
- CAS: 697761-98-1
- MF: C23H23ClFNO5
- MW: 447.88
- EINECS:1592732-453-0
- MDL Number:MFCD11846134
- Synonyms:Elvitegravir,EVG,GS-9137,JTK-303;(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO;6-[(3-chloro-2-fluorophenyl)Methyl]-1-[(2S)-1-hydroxy-2,3-diMethylbutan-2-yl]-7-Methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;GS 9137;JTK 303;6-[(3-Chloro-2-fluorophenyl)Methyl]-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]-7-Methoxy-4-oxo-3-quinolinecarboxylic Acid;D06677;EVG
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Properties
Melting point :93-96°C
Boiling point :623.6±55.0 °C(Predicted)
Density :1.357±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.44±0.20(Predicted)
form :Solid
color :Off-White to Pale Yellow
InChIKey :JUZYLCPPVHEVSV-LJQANCHMSA-N
SMILES :N1([C@H](CO)C(C)C)C2=C(C=C(CC3=CC=CC(Cl)=C3F)C(OC)=C2)C(=O)C(C(O)=O)=C1
CAS DataBase Reference :697761-98-1
Boiling point :623.6±55.0 °C(Predicted)
Density :1.357±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.44±0.20(Predicted)
form :Solid
color :Off-White to Pale Yellow
InChIKey :JUZYLCPPVHEVSV-LJQANCHMSA-N
SMILES :N1([C@H](CO)C(C)C)C2=C(C=C(CC3=CC=CC(Cl)=C3F)C(OC)=C2)C(=O)C(C(O)=O)=C1
CAS DataBase Reference :697761-98-1
Safety Information
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Description
Elvitegravir is a quinolone antibiotic that inhibits the integrase of HIV-1 (IC50 = 7.2 nM). It blocks the integration of HIV-1 cDNA through the inhibition of DNA strand transfer. Elvitegravir is used in combination with a pharmacoenhancer and nucleoside/nucleotide reverse transcriptase inhibitors to block HIV-1 replication in vivo.More related product prices
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