NMS 873
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- ₹14440.55 - ₹58151.9
- Product name: NMS 873
- CAS: 1418013-75-8
- MF: C27H28N4O3S2
- MW: 520.67
- EINECS:200-256-5
- MDL Number:MFCD28009371
- Synonyms:NMS 873;NMS873;NMS-873;NMS873/NMS-873;3-[3-(CYCLOPENTYLSULFANYL)-5-({[2-METHYL-4'-(METHYLSULFONYL)-4-BI PHENYLYL]OXY}METHYL)-4H-1,2,4-TRIAZOL-4-YL]PYRIDINE;Pyridine, 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-;3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine NMS-873;NMS 873 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1128
- Product descriptionNMS-873 ≥98% (HPLC)
- Packaging5MG
- Price₹14440.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.31088
- Product descriptionVCP Inhibitor III, NMS-873 - CAS 1418013-75-8 - Calbiochem A cell-permeable, non-ATP competitive, allosteric inhibitor of VCP ATPase (IC?? = 20 nM with 1 mM ATP)
- Packaging10MG
- Price₹21209.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1128
- Product descriptionNMS-873 ≥98% (HPLC)
- Packaging25MG
- Price₹58151.9
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1128 | NMS-873 ≥98% (HPLC) | 5MG | ₹14440.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.31088 | VCP Inhibitor III, NMS-873 - CAS 1418013-75-8 - Calbiochem A cell-permeable, non-ATP competitive, allosteric inhibitor of VCP ATPase (IC?? = 20 nM with 1 mM ATP) | 10MG | ₹21209.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1128 | NMS-873 ≥98% (HPLC) | 25MG | ₹58151.9 | 2022-06-14 | Buy |
Properties
Melting point :>220°C (dec.)
Boiling point :769.3±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble25mg/mL, clear
pka :2.48±0.12(Predicted)
form :powder
color :white to beige
Boiling point :769.3±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble25mg/mL, clear
pka :2.48±0.12(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.Related product price
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