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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Glycine derivative >ON-01910

ON-01910

ON-01910 Structure
  • ₹0
  • Product name: ON-01910
  • CAS: 1225497-78-8
  • MF: C21H26NNaO8S
  • MW: 475.49
  • EINECS:-0
  • MDL Number:MFCD11655911
  • Synonyms:ON-01910;Estybon;N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt;ON 01910 sodium salt;ON-01910;ESTYBON;Rigosertib (ON-01910);N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1);N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt Rigosertib (ON-01910)
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Properties

Melting point :>256oC (dec.)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :Pale Yellow to Pale Green

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling. It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines. ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models.

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