ONO-AE3-208
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- ₹13390.53 - ₹53854.38
- Product name: ONO-AE3-208
- CAS: 402473-54-5
- MF: C24H21FN2O3
- MW: 404.43
- EINECS:
- MDL Number:MFCD13184814
- Synonyms:4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid;ONO-AE3-208;AE 3-208;ONO-AE3-208;AE 3-208;ONO AE3 208;AE 3-208;ONO AE3 208;Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-;4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid;4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2076
- Product descriptionONO-AE3-208 ≥98% (HPLC)
- Packaging5MG
- Price₹13390.53
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2076
- Product descriptionONO-AE3-208 ≥98% (HPLC)
- Packaging25MG
- Price₹53854.38
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2076 | ONO-AE3-208 ≥98% (HPLC) | 5MG | ₹13390.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2076 | ONO-AE3-208 ≥98% (HPLC) | 25MG | ₹53854.38 | 2022-06-14 | Buy |
Properties
Boiling point :662.4±55.0 °C(Predicted)
Density :1.30
storage temp. :-20°C
solubility :≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic
pka :4.69±0.10(Predicted)
form :powder
color :white to beige
Density :1.30
storage temp. :-20°C
solubility :≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic
pka :4.69±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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Description
ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt damage, and inflammation, after treatment with 3% dextran sodium sulfate. ONO-AE3-208 has also been used to implicate EP4 signaling in immune and autoimmune responses, inflammation, and cancer.More related product prices
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