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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Grapiprant

Grapiprant

Grapiprant Structure
  • ₹0
  • Product name: Grapiprant
  • CAS: 415903-37-6
  • MF: C26H29N5O3S
  • MW: 491.61
  • EINECS:
  • MDL Number:MFCD16628076
  • Synonyms:CJ-023423;Grapiprant;2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine;AAT 007;MR 10A7;RQ 00000007;RQ 7;Grapiprant (CJ-023423)
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Properties

Melting point :>151°C (dec.)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 10 mg/ml)
pka :5.19±0.10(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :HZVLFTCYCLXTGV-UHFFFAOYSA-N
SMILES :C1(S(NC(NCCC2=CC=C(N3C4C=C(C)N=C(C)C=4N=C3CC)C=C2)=O)(=O)=O)=CC=C(C)C=C1

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively). It inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2. CJ-023423 reduces acute and chronic inflammatory pain in different mouse models.

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