Grapiprant
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- ₹0
- Product name: Grapiprant
- CAS: 415903-37-6
- MF: C26H29N5O3S
- MW: 491.61
- EINECS:
- MDL Number:MFCD16628076
- Synonyms:CJ-023423;Grapiprant;2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine;AAT 007;MR 10A7;RQ 00000007;RQ 7;Grapiprant (CJ-023423)
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :>151°C (dec.)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 10 mg/ml)
pka :5.19±0.10(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :HZVLFTCYCLXTGV-UHFFFAOYSA-N
SMILES :C1(S(NC(NCCC2=CC=C(N3C4C=C(C)N=C(C)C=4N=C3CC)C=C2)=O)(=O)=O)=CC=C(C)C=C1
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 10 mg/ml)
pka :5.19±0.10(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :HZVLFTCYCLXTGV-UHFFFAOYSA-N
SMILES :C1(S(NC(NCCC2=CC=C(N3C4C=C(C)N=C(C)C=4N=C3CC)C=C2)=O)(=O)=O)=CC=C(C)C=C1
Safety Information
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Description
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively). It inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2. CJ-023423 reduces acute and chronic inflammatory pain in different mouse models.More related product prices
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Suppliers and manufacturers
Zenfold Sustainable Technologies (ZST)
CLEARSYNTH LABS LTD.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
ANHUI WITOP BIOTECH CO., LTD
Guangzhou TongYi biochemistry technology Co.,LTD
InvivoChem
Nanjing Doge Biomedical Technology Co., Ltd