JZL 184
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- ₹11880.01 - ₹17612.28
- Product name: JZL 184
- CAS: 1101854-58-3
- MF: C27H24N2O9
- MW: 520.49
- EINECS:
- MDL Number:
- Synonyms:4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester;1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184;JZL 184;JZL 184 JZL184 JZL-184;MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem;JZL-184; JZL 184
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number475741
- Product descriptionMAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL.
- Packaging10MG
- Price₹11880.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberJ3455
- Product descriptionJZL 184 hydrate ≥97% (HPLC)
- Packaging5MG
- Price₹17612.28
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 475741 | MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL. | 10MG | ₹11880.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | J3455 | JZL 184 hydrate ≥97% (HPLC) | 5MG | ₹17612.28 | 2022-06-14 | Buy |
Properties
Melting point :116-120°C
Boiling point :706.4±60.0 °C(Predicted)
Density :1.467±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :White to off-white solid
pka :13.32±0.29(Predicted)
color :light yellow to yellow-green
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
CAS DataBase Reference :1101854-58-3
Boiling point :706.4±60.0 °C(Predicted)
Density :1.467±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :White to off-white solid
pka :13.32±0.29(Predicted)
color :light yellow to yellow-green
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
CAS DataBase Reference :1101854-58-3
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.Related product price
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