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ChemicalBook > Product Catalogue >API >Diagnostic agents >Organ Function Test agent >PENTAGASTRIN

PENTAGASTRIN

PENTAGASTRIN Structure
  • ₹20437.6 - ₹65144.85
  • Product name: PENTAGASTRIN
  • CAS: 5534-95-2
  • MF: C37H49N7O9S
  • MW: 767.9
  • EINECS:226-889-7
  • MDL Number:MFCD00076515
  • Synonyms:T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2;aspartyl]-l-phenylalaninamide ;ay6608 ;boc-beta-ala-try-met-asp-phe(nh2) ;gastrodiagnost ;ici50123 ;lanineamide ;l-methionyl-l-alpha-aspartyl-
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberB1636
  • Product descriptionPentagastrin ≥95% (HPLC), powder
  • Packaging25MG
  • Price₹20437.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB1636
  • Product descriptionPentagastrin ≥95% (HPLC), powder
  • Packaging100MG
  • Price₹65144.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) B1636 Pentagastrin ≥95% (HPLC), powder 25MG ₹20437.6 2022-06-14 Buy
Sigma-Aldrich(India) B1636 Pentagastrin ≥95% (HPLC), powder 100MG ₹65144.85 2022-06-14 Buy

Properties

Melting point :229-230° (dec)
alpha :D22 -28.8 ±0.5° (DMF)
Boiling point :1196.6±65.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
form :powder
pka :4.19±0.10(Predicted)
color :White to off-white
Sequence :N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey :NEYNJQRKHLUJRU-DZUOILHNSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

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