Paroxetine hydrochloride
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- Product name: Paroxetine hydrochloride
- CAS: 78246-49-8
- MF: C19H21ClFNO3
- MW: 365.83
- EINECS:616-601-1
- MDL Number:MFCD00797405
- Synonyms:PAROMOMYCINSULFATE;(3s,4r)-orid ;(3s-trans)-id ;3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,hydrochloride,(3s-trans)-piperidin ;3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidinhydrochl ;PAROXETINE HC;Paroxetine hydrochloride,trans-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride;(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride hemihydrate
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Properties
Melting point :129-131°C
storage temp. :2-8°C
solubility :insoluble in H2O; ≥17.8 mg/mL in EtOH; ≥18.29 mg/mL in DMSO
form :Solid
color :White to off-white
CAS DataBase Reference :78246-49-8(CAS DataBase Reference)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥17.8 mg/mL in EtOH; ≥18.29 mg/mL in DMSO
form :Solid
color :White to off-white
CAS DataBase Reference :78246-49-8(CAS DataBase Reference)
Safety Information
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Description
Paroxetine is a phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the human serotonin transporter with a Ki value of 0.72 nM. It less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1,900 nM, respectively). Paroxetine also inhibits, at concentrations in excess of 1 μM, nitric oxide synthase activity in the cytosol of hamster brain. Selective serotonin uptake inhibitors, including paroxetine, are used in cases of depression and anxiety disorder.More related product prices
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