Proglumide
- ₹0
- Product name: Proglumide
- CAS: 6620-60-6
- MF: C18H26N2O4
- MW: 334.41
- EINECS:229-567-4
- MDL Number:MFCD00055071
- Synonyms:PROGLUMIDE;(+/-)-4-benzamido-n,n-dipropylglutaramic acid;LABOTEST-BB LT00772215;N(2)-benzoyl-N,N-dipropyl-alpha-glutamine;4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid;4-BenzaMido-5-(dipropylaMino)-5-oxopentanoic acid;N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine;(+-)-pentanoicaci
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Properties
Melting point :148-150°C
Boiling point :471.21°C (rough estimate)
Density :1.1944 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :4.51±0.10(Predicted)
color :Crystals
CAS DataBase Reference :6620-60-6(CAS DataBase Reference)
EPA Substance Registry System :Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)
Boiling point :471.21°C (rough estimate)
Density :1.1944 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :4.51±0.10(Predicted)
color :Crystals
CAS DataBase Reference :6620-60-6(CAS DataBase Reference)
EPA Substance Registry System :Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)
Safety Information
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Description
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
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