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ChemicalBook > Product Catalogue >API >Digestive system drugs >Antacid and Mucosal protective Drugs >Proglumide

Proglumide

Proglumide Structure
  • ₹0
  • Product name: Proglumide
  • CAS: 6620-60-6
  • MF: C18H26N2O4
  • MW: 334.41
  • EINECS:229-567-4
  • MDL Number:MFCD00055071
  • Synonyms:PROGLUMIDE;(+/-)-4-benzamido-n,n-dipropylglutaramic acid;LABOTEST-BB LT00772215;N(2)-benzoyl-N,N-dipropyl-alpha-glutamine;4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid;4-BenzaMido-5-(dipropylaMino)-5-oxopentanoic acid;N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine;(+-)-pentanoicaci
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :148-150°C
Boiling point :471.21°C (rough estimate)
Density :1.1944 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :4.51±0.10(Predicted)
color :Crystals
CAS DataBase Reference :6620-60-6(CAS DataBase Reference)
EPA Substance Registry System :Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

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