RET Kinase inhibitor 1
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- ₹0
- Product name: RET Kinase inhibitor 1
- CAS: 1627856-64-7
- MF: C22H21F4N3O4
- MW: 467.41
- EINECS:
- MDL Number:MFCD30747847
- Synonyms:RET Kinase inhibitor 1;CS-2597;c-RET inhibitor GS3179106;GSK3179106;GSK-3179106;Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-;syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106
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Properties
Boiling point :670.1±55.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM) form :A crystalline solid
pka :10.30±0.10(Predicted)
color :White to off-white
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM) form :A crystalline solid
pka :10.30±0.10(Predicted)
color :White to off-white
Safety Information
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Description
GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.Related product price
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