GSK461364
|
- ₹0
- Product name: GSK461364
- CAS: 929095-18-1
- MF: C27H28F3N5O2S
- MW: 543.6
- EINECS:200-258-5
- MDL Number:MFCD12755419
- Synonyms:(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide;GSK-461364A;GSK461364(GSK-461364);5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl];5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phen;GSK461364;GSK-461364;GSK4613
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :>150°C (dec.)
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. GSK461364 is a potent, reversible inhibitor of Plk1 (Ki = 2.2 nM). It is less effective against Plk2 and Plk3 (Kis = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases. GSK461364 dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis. It appears to be more effective against p53-deficient tumors and is able to cross the blood-brain barrier. GSK461364 is effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.Related product price
- PD 0325901
₹15891.1-60457.63 - Bortezomib
₹12940 - 188591-46-0
₹16460-68901.13
