RN-1 (hydrochloride)
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- Product name: RN-1 (hydrochloride)
- CAS: 1781835-13-9
- MF: C23H30ClN3O2
- MW: 415.96
- EINECS:
- MDL Number:MFCD32200435
- Synonyms:RN-1 (hydrochloride);1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride;RN 1 dihydrochloride;RN1; RN 1;disease,RN1,RN 1 dihydrochloride,Histone Demethylase,inhibit,hemoglobin,fetal,RN1 dihydrochloride,brain-penetrant,LSD1,Inhibitor,HbF,sickle,RN 1,cell,RN-1,irreversible
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Properties
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥2.7 mg/mL in DMSO with ultrasonic; ≥8.47 mg/mL in H2O
form :crystalline solid
color :White to off-white
solubility :insoluble in EtOH; ≥2.7 mg/mL in DMSO with ultrasonic; ≥8.47 mg/mL in H2O
form :crystalline solid
color :White to off-white
Safety Information
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Description
Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs). RN-1 is a potent, irreversible inhibitor of LSD1 (IC50 = 70 nM). It is much less effective against MAO-A and MAO-B (IC50s = 0.51 and 2.8 μM, respectively). Following intraperitoneal administration, RN-1 penetrates the blood-brain barrier and distributes in mice to a brain/plasma exposure ratio of 88.9. It blocks long-term but not short-term memory in mice. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice.Related product price
- 946387-07-1
₹8746.6-33860.6
Suppliers and manufacturers
TargetMol Chemicals Inc.
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Shanghai EFE Biological Technology Co., Ltd.
DC Chemicals