RKI1447
![]() |
- ₹0
- Product name: RKI1447
- CAS: 1342278-01-6
- MF: C16H14N4O2S
- MW: 326.37
- EINECS:200-256-5
- MDL Number:MFCD26142658
- Synonyms:RKI1447;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-;1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447;RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea;RKI-1447, >=98%;CS-855;RKI 1447; RKI1447
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|
Properties
Melting point :>205oC (dec.)
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Safety Information
Symbol(GHS): |
![]() |
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).More related product prices
AZD-9291 864082-47-3 Fasudil hydrochloride 1,9-Pyrazoloanthrone Y27632 (hydrochloride) Thiazovivin RN486 946387-07-1 RN-1 (hydrochloride)Related product price
- Fasudil hydrochloride
₹7800 - 1,9-Pyrazoloanthrone
₹6100-60295.25 - Y27632 (hydrochloride)
₹14800-90886.7