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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >Dopamine Receptor agonists >ROTIGOTINE

ROTIGOTINE

ROTIGOTINE Structure
  • ₹3000 - ₹10500
  • Product name: ROTIGOTINE
  • CAS: 99755-59-6
  • MF: C19H25NOS
  • MW: 315.47
  • EINECS:
  • MDL Number:MFCD00870193
  • Synonyms:()-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-napht hol;(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol;N 0923;SPM 962;(S)-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol;[2S,(-)]-N-Propyl-N-[2-(2-thienyl)ethyl]-5-hydroxy-1,2,3,4-tetrahydro-2β-naphthalenamine;[S,(-)]-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol;S(-)-N-0437
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • TCI Chemicals (India)

Package

  • 10MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberR0220
  • Product descriptionRotigotine
  • Packaging10MG
  • Price₹3000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberR0220
  • Product descriptionRotigotine
  • Packaging50MG
  • Price₹10500
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) R0220 Rotigotine 10MG ₹3000 2022-05-26 Buy
TCI Chemicals (India) R0220 Rotigotine 50MG ₹10500 2022-05-26 Buy

Properties

Melting point :78 °C
Boiling point :470.1±45.0 °C(Predicted)
Density :1.15±0.1 g/cm3(Predicted)
storage temp. :room temp
Water Solubility :Insoluble in water
solubility :DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
pka :10.49±0.40(Predicted)
form :powder to crystal
color :White to Almost white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P281 Use personal protective equipment as required.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

While levodopa is still considered the cornerstone of treatment of Parkinson’s disease, many patients begin to experience treatment-related problems, such as a wearing-off phenomenon and the development of dyskinesias as the disease progresses. Continuous dopaminergic stimulation by means of a dopamine agonist has been recognized as being associated with a lower incidence of dyskinesias. Using a selective dopamine agonist as monotherapy in early disease may delay the onset of levodopa therapy, or at a minimum, lower its dose in adjunctive situations to minimize the adverse neurotoxic effects of levodopa. Rotigotine is a nonergolinic dopamine D3/D2/D1 receptor agonist, and it is the first dopamine agonist to be launched as a transdermal patch.

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Suppliers and manufacturers

Mylan Laboratories Ltd Maithri Drugs Pvt Ltd Clearsynth Labs Pharma Affiliates Anantco Enterprises Pvt., Ltd. Daga Global Chemicals Pvt., Ltd. (DGCPL) MYLAN LABORATORIES LIMITED Anika International Pvt. Limited Manus Aktteva Biopharma LLP Oceanic Pharmachem Pvt. Ltd.